Nucleic Acids Research, 1988, Vol. 16, No. 15 7487-7497
© 1988
Articles |
Drosophila has a single copy of the gene encoding a highly conserved histone H2A variant of the H2A. F/Z type
Department of Biology, Washington University St Louis, MO 63130 1Department of Biology, University of Rochester Rochester, NY 14627, USA
Received April 12, 1988. Revised June 21, 1988. Accepted June 21, 1988.
The Tetrahymena histone H2A variant designated hv1 is localized exclusively in the transcriptionally active macronuclous and is absent from the quiescent micronucleus (1) . A cDNA clone of tha hv1 gene (2) was used to screen a Drosophila cDNA library. A cross-hybridizing clone was recovered and shown by sequence analysis to code for a protein homologous to hv1 as well as to the chicken H2A variant, H2A.F (3), the sea urchin H2A variant, H2A.F/Z (4) and the mammalian H2A variant H2A.Z (5). Southern analysis of Drosophlia genomic DNA indicates that the H2AvD (H2A variant Drosophila) gene is present in one copy. In situ hybridisation places the locus at 97CD on chromosome 3, while the S-phase regulated histone genes are on chromosome 2 (6). Thus the Drosophlla H2A variant should be accessible to genetic analysis, which will enable its function to be determined.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  X. Song, E. Gjoneska, Q. Ren, S. D. Taverna, C. D. Allis, and M. A. Gorovsky Phosphorylation of the SQ H2A.X Motif Is Required for Proper Meiosis and Mitosis in Tetrahymena thermophila Mol. Cell. Biol., April 1, 2007; 27(7): 2648 - 2660. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. B. Millar, F. Xu, K. Zhang, and M. Grunstein Acetylation of H2AZ Lys 14 is associated with genome-wide gene activity in yeast. Genes & Dev., March 15, 2006; 20(6): 711 - 722. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. T. Kamakaka and S. Biggins Histone variants: deviants? Genes & Dev., February 1, 2005; 19(3): 295 - 316. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Swaminathan, E. M. Baxter, and V. G. Corces The role of histone H2Av variant replacement and histone H4 acetylation in the establishment of Drosophila heterochromatin Genes & Dev., January 1, 2005; 19(1): 65 - 76. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Chioda, F. Spada, R. Eskeland, and E. M. Thompson Histone mRNAs Do Not Accumulate during S Phase of either Mitotic or Endoreduplicative Cycles in the Chordate Oikopleura dioica Mol. Cell. Biol., June 15, 2004; 24(12): 5391 - 5403. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Ren and M. A. Gorovsky The Nonessential H2A N-Terminal Tail Can Function as an Essential Charge Patch on the H2A.Z Variant N-Terminal Tail Mol. Cell. Biol., April 15, 2003; 23(8): 2778 - 2789. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. P. Madigan, H. L. Chotkowski, and R. L. Glaser DNA double-strand break-induced phosphorylation of Drosophila histone variant H2Av helps prevent radiation-induced apoptosis Nucleic Acids Res., September 1, 2002; 30(17): 3698 - 3705. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. W. Abbott, V. S. Ivanova, X. Wang, W. M. Bonner, and J. Ausio Characterization of the Stability and Folding of H2A.Z Chromatin Particles. IMPLICATIONS FOR TRANSCRIPTIONAL ACTIVATION J. Biol. Chem., November 2, 2001; 276(45): 41945 - 41949. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L A Stargell, J Bowen, C A Dadd, P C Dedon, M Davis, R G Cook, C D Allis, and M A Gorovsky Temporal and spatial association of histone H2A variant hv1 with transcriptionally competent chromatin during nuclear development in Tetrahymena thermophila. Genes & Dev., December 1, 1993; 7(12b): 2641 - 2651. [Abstract] [PDF]
|
|