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Nucleic Acids Research, 1988, Vol. 16, No. 15 7703-7712
© 1988

Articles

The role of the excision-repair enzymes' in mutation-induction by cic-Pt(NH3)2Cl2

Jaap Brouwer, Lucie Vollebregt and Pieter van de Putte

Laboratory of Molecular Genetics, Leiden University Wassenaarseweg 64, 2333A1 Leiden, The Netherlands

Received March 17, 1988. Revised June 28, 1988. Accepted June 28, 1988.

Mutation induction by cis-Pt(NH3)2Cl2 (cisplatin) has been shown to be absent in E.coli strains carrying a deletion of the uvrB gene (1). This suggested that excision-repair, which is normally thought to be error-free, is involved in mutation Induction with cisplatin. Here, the role of the excision repair enzymes UvrA, UvrB and UvrC is investigated using E.coli strains with different repair capacities. It is shown that cisplatin induced mutagenesis is dependent both on UvrA and UvrB but not on UvrC. Of the UvrB enzyme the N-terminal 113 aminoacids are sufficient for mutation induction by cisplatin.


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