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Nucleic Acids Research, 1988, Vol. 16, No. 16 8147-8156
© 1988

Articles

60Co {gamma}-rays induce predominantly C/G to G/C transversions in double-stranded M13 DNA

Barbara Hoebee1, Jaap Brouwer2, Pieter van de Putte2, Henk Loman1 and Jan Retel1,3

1Department of Biophysics, Physics Laboratory of the Free University Dc Boelelaan 1081, 1081 1{V Amsterdam 2Laboratory of Molecular Genetics, State University of Leiden 2333 AL Leiden 3Department of Oncology, Free University Hospital De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands

Received April 13, 1988. Revised June 21, 1988. Accepted July 20, 1988.

Upon irradiation with gamma rays of an oxygenated aqueoua solution of double-stranded M13 DNA, a very specific mutation spectrum was found with respect to both the type and the positions in the DNA sequence. Of the 23 mutations, which were sequenced, 16 represent a C/G to G/C tranaversion. A C/G to T/A transition was found once and a G/C to T/A tranaversion twice. The remaining 4 mutations are frsmeshifts, 2 are identical and formed by the insertion of a G/C basepair; the other 2 mutations are due to a duplication of 10 basepaira situated at different positions but with a remarkable homology in base sequence. Fourteen mutationa, including the 2 duplications are found in the neighbourhood of a TGCT/ACGA sequence.


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