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Nucleic Acids Research, 1988, Vol. 16, No. 17 8351-8360
© 1988

Articles

Functional role of a highly repetitive DNA sequence in anchorage of the mouse genome

Beatrice Neuer-Nitsche, Xiang Lu and Dieter Werner

Institut für Zell- und Tumorbiologie, Deutsches Krebsforschungszentrum Im Neuenheimer Feld 280, D-6900 Heidelberg, FRG

Received June 24, 1988. Revised August 15, 1988. Accepted August 15, 1988.

The major portion of the eukaryotic genome consists of various categories of repetitive DNA sequences which have been studied with respect to their base compositions, organizations, copy numbers, transcription and species specificities [1]; their biological roles, however, are still unclear. A novel quality of a highly repetitive mouse DNA sequence is described which points to a functional role: All copies (approximately 50,000 per haploid genome) of this DNA sequence reside on genomic AIu I DNA fragments each associated with nuclear polypeptides that are not released from DNA by proteinase K, SDS and phenol extraction. By this quality the repetitive DNA sequence is classified as a member of the sub-set of DNA sequences involved in tight DNA-polypeptide complexes wich have been previously shown to be components of the subnuclear structure termed ‘nuclear matrix’ [2, 3, 4]. From these results it has to be concluded that the repetitive DNA sequence characterized in this report represents or comprizes a signal for a large number of site specific attachment points of the mouse genome in the nuclear matrix.


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