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Nucleic Acids Research, 1988, Vol. 16, No. 18 8817-8833
© 1988

Articles

Illegitimate recombination in the histone multigenic family generates circular DNAs in Drosophila embryos

Geneviève Pont+, Fabienne Degroote and Georges Picard*

Laboratoire de Génétique, UA 360 CNRS, Université Blaise Pascal-Clermont-Fd. II 63177 Aubiére cedex, France

*To whom correspondence should be addressed

Received June 10, 1988. Revised August 16, 1988. Accepted August 16, 1988.

From extrachromosomal covalently closed circular DNA molecules purified from Drosophila melanogaster embryos, we have isolated 24 clones homologous to the histone tandemly repeated gene family. Some of the clones harbor one of the two main types of genomic repeated units of 4.8 and 5.0 kb. and probably result from homologous recombination. The remaining clones have a size ranging from 0.2 to 2.5 kb. and most of them carry a single fragment of the repeated unit. Nucleotide sequences of the junction region of six of these clones indicate they are generated by illegitimate recombination between short (8–15 bp.) imperfect direct repeats. The data suggest that most of the histone homologous circular DNA molecules are deleted histone units.

+Present address: Department of Biology, University of Utah, Salt-Lake City, UT 84112, USA


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