Nucleic Acids Research, 1988, Vol. 16, No. 2 739-749
© 1988
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The F-type 5' motif of mouse L1 elements: a major class of L1 termini similar to the A-type in organization but unrelated in sequence
Curriculum in Genetics, Department of Microbiology and Immunology, Program in Molecular Biology and Biotechnology, University of North Carolina Chapel Hill, NC 27514, USA
Received September 4, 1987. Revised December 14, 1987. Accepted December 14, 1987.
It has previously been shown that the LI family in the mouse (LlMd) contains two alternative 5' ends called the A- and F-type sequences (1,2). We show here that the F-type element is a major class of murine LI elements and report on the details of organization of the 5' motif of these F-type elements. Although the A- and F-type 5' sequences share no detectable sequence homology the organization of an F-type 5' end is strikingly similar to that of an A-type. That is, the F-type 5' sequences consist of a tandem array of a small number of 206 bp monomers while the A-type 5' motif consists of a tandem array of 208 bp monomers. All of the A-type elements characterized to date have a truncated monomer at the 5' end of the array. Many of the F-type elements are also terminated at the 5' end by a truncated copy but unlike the A-type elements some F-type elements terminate with a monomer which is within a few nucleotides of being complete. In addition the F-type consensus sequence, in contrast to the A-type sequence, shows homology (70%) to the body of the LIMd starting at the position where the monomer joins the rest of the LI element.
*Present address: Department of Cellular and Developmental Biology, Harvard University, Cambridge, MA 02138, USA
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