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Nucleic Acids Research, 1988, Vol. 16, No. 20 9587-9596
© 1988

Articles

Characterization of DNA polymerase ß mRNA: cell-cycle and growth response in cultured human cells

B.Z. Zmudzka, A. Fomace2, J. Collins1 and S.H. Wilson

Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health Bethesda, MD 20892 1Department of Biochemistry, Medical College of Virginia Richmond, VA 23298 2Radiation Oncology Branch, National Cancer Institute, National Institutes of Health Bethesda, MD 20892, USA

Received July 8, 1988. Accepted September 16, 1988.

DNA polymerase ß (ß-polymerase) is a housekeeping enzyme involved in DNA repair in vertebrate cells. We used a cDNA probe to study abundance of ß-polymerase mRNA in cultured human cells. The mRNA level in synchronized HeLa cells, representing different stages of the cell-cycle, varied only slightly. Contact inhibited fibroblasts AG-1522 contained the same level of mRNA as growing cells. The steady-state level of mRNA in fibroblasts is equivalent to 6 molecules per cell. The results indicate that the ß-polymerase transcript is "low abundance" and is neither cell-cycle nor growth phase responsive.


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