Skip Navigation

This Article
Right arrow Print PDF (2845K)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Porter, G. L.
Right arrow Articles by Wise, J. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Porter, G. L.
Right arrow Articles by Wise, J. A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nucleic Acids Research, 1988, Vol. 16, No. 21 10131-10152
© 1988

MOLECULAR BIOLOGY

The sequence of U3 from Schizosaccharomyces pombe suggests structural divergence of this snRNA between metazoans and unicellular eukaryotes

Gregory L. Porter*, Patrick J. Brennwald, Kristin A. Holm and Jo Ann Wise

Department of Biochemistry, University of Illinois Urbana, IL 61801, USA

*To whom correspondence should be addressed

Received August 2, 1988. Accepted September 30, 1988.

We have cloned and sequenced one of the two genes encoding a 255 nucleotide small nuclear RNA from the fission yeast Schizosaccharomyces pombe. Based on the presence of four regions of primary sequence conservation and a predicted secondary structure similar to that previously proposed for human U3, we conclude that this molecule is the fission yeast homologue of this mammalian snRNA. The 5' one-third of fission yeast U3 is, however, unable to form a single stable hairpin as proposed for this region of the human RNA, but rather folds into two stem-loop structures. By analogy to fission yeast U3, we propose revised secondary structures containing two hairpins for this portion of the U3-like snRNAs from Saccharomyces cerevisiae and Dictyostelium discoideum. Thus, our data suggest that the structure of U3 snRNA has diverged in lower and higher eukaryotes.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Nucleic Acids ResHome page
W. A. Speckmann, R. M. Terns, and M. P. Terns
The Box C/D motif directs snoRNA 5'-cap hypermethylation
Nucleic Acids Res., November 15, 2000; 28(22): 4467 - 4473.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
A. A. Lukowiak, S. Granneman, S. A. Mattox, W. A. Speckmann, K. Jones, H. Pluk, W. J. v. Venrooij, R. M. Terns, and M. P. Terns
Interaction of the U3-55k protein with U3 snoRNA is mediated by the Box B/C motif of U3 and the WD repeats of U3-55k
Nucleic Acids Res., September 15, 2000; 28(18): 3462 - 3471.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
M. Antal, A. Mougin, M. Kis, E. Boros, G. Steger, G. Jakab, F. Solymosy, and C. Branlant
Molecular characterization at the RNA and gene levels of U3 snoRNA from a unicellular green alga, Chlamydomonas reinhardtii
Nucleic Acids Res., August 1, 2000; 28(15): 2959 - 2968.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
W. Speckmann, A. Narayanan, R. Terns, and M. P. Terns
Nuclear Retention Elements of U3 Small Nucleolar RNA
Mol. Cell. Biol., December 1, 1999; 19(12): 8412 - 8421.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
D. A. Samarsky and M. J. Fournier
Functional Mapping of the U3 Small Nucleolar RNA from the Yeast Saccharomyces cerevisiae
Mol. Cell. Biol., June 1, 1998; 18(6): 3431 - 3444.
[Abstract] [Full Text]

Home page
 Genes Dev.Home page
K T Tycowski, M D Shu, and J A Steitz
A small nucleolar RNA is processed from an intron of the human gene encoding ribosomal protein S3.
Genes & Dev., July 1, 1993; 7(7a): 1176 - 1190.
[Abstract] [PDF]

Home page
 Genes Dev.Home page
S J Baserga, M Gilmore-Hebert, and X W Yang
Distinct molecular signals for nuclear import of the nucleolar snRNA, U3.
Genes & Dev., June 1, 1992; 6(6): 1120 - 1130.
[Abstract] [PDF]

Home page
 ScienceHome page
E Myslinski, V Segault, and C Branlant
An intron in the genes for U3 small nucleolar RNAs of the yeast Saccharomyces cerevisiae
Science, March 9, 1990; 247(4947): 1213 - 1216.
[Abstract] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.