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Nucleic Acids Research, 1988, Vol. 16, No. 21 10213-10224
© 1988

MOLECULAR BIOLOGY

Human 28S ribosomal RNA sequence heterogeneity

Iris Laudien Gonzalez+,*, James E. Sylvester+ and Roy D. Schmickel

Department of Human Genetics, University of Pennsylvania Philadelphia, PA 19104, USA

*To whom correspondence should be addressed

Received July 7, 1988. Accepted October 5, 1988.

DNA sequencing of several cloned human 285 ribosomal RNA gene fragments has revealed sequence heterogeneity (1) but it was not clear whether these are inactive pseudogenes or are active genes that are transcribed and represented in ribosomes. S1 nuclease analysis allowed us to examine the population of ribosomal RNA molecules of a cell, and we found that 28S rRNA is a heterogeneous assortment of molecules in both mono- and polysomal preparations. Sequence variation, although largely concentrated in variable regions of the molecule, apparently also occurs in the conserved regions.

+Present address: Hahnemann University, Pathology Department, Broad and Vine, Philadelphia PA 19102–1192, USA


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