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Nucleic Acids Research, 1988, Vol. 16, No. 21 9979-9993
© 1988

MOLECULAR BIOLOGY

A new member of the ras gene superfamily identified in a rat liver cell line

Cecilia Bucci, Rodolfo Frunzio, Lorenzo Chiariotti, Alexandra L. Brown1, Matthew M. Rechler1 and Carmelo B. Bruni

Dipartimento di Biologia e Patologia Cellulare e Molecolare, Centro di Endocrinologia ed Oncologia Sperimentale del CNR, Università di Napoli Via S.Pansini 5, 80131 Naples, Italy 1Molecular, Cellular and Nutritional Endocrinology Branch NIDDK, NIH, Bethesda, MD 20892, USA

Received August 26, 1988. Accepted October 3, 1988.

A new member of the ras genes superfamily was isolated from a cDNA library derived from a rat liver cell line (BRL-3A). The predicted 201 amino acids ras-like protein shows 30–35% homology with other members of the ras and ras-related gene products so far described. Conserved features include the GTP-binding and hydrolysis domains and the carboxyl terminal cysteine residues. A protein of the expected size (Mr 23,000) was synthesized in an in vitro transcription-translation system. The BRL-ras gene 1s present in single copy in the rat genome and is ubiquitously expressed at high levels in all tissues and cell lines examined.


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