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Nucleic Acids Research, 1988, Vol. 16, No. 22 10575-10592
© 1988

MOLECULAR BIOLOGY

An embryonic DNA-binding protein specific for a region of the human IFNß1, promoter

Allison Haggarty, Ponton André, Gary D. Paterno+, Luc Daigneault and Daniel Skup

Institut du Cancer de Montréal 1560 Sherbrooke Est., Montréal, Québec H2L 4M1, Canada

Received August 12, 1988. Revised October 18, 1988. Accepted October 18, 1988.

Embryonal carcinoma (EC) cells are unable to make interferon in response to inducing agents. This block disappears after differentiation. We have found that nuclear extracts from undifferentiated P19 EC cells contain a DNA-binding activity which specifically recognizes a region within the human interferon-ß1 promoter. This activity is absent from differentiated cell types, both of EC and non-EC origin. The binding of the factor in undifferentiated EC cells leads to dramatic changes in the overall protein binding pattern of the interferon promoter as compared with differentiated cells, and may be responsible for repression of the endogenous interferon-ß gene prior to differentiation.

+Present address: Development Biology Unit, Imperial Cancer Research Fund, Department of Zoology, University of Oxford, South Parks Road, Oxford, OX1 3PS, UK


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