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Nucleic Acids Research, 1988, Vol. 16, No. 23 11355-11364
© 1988

MOLECULAR BIOLOGY

The structure of V{alpha} and J{alpha} segments in the mouse

Jordi Yague{boxplus},, Marcia Blackman, Willi Born1, Marrack Phillipa1, Kappler John1 and Palmer Ed*

Departments of Medicine and Pediatrics Denver, CO, USA 1Howard Hughes Medical Institute, National Jewish Center for Immunology and Respiratory Medicine Denver, CO, USA

{boxplus}Department of Immunology, Hospital Clinico, Barcelona, Catalunya, Spain

*To whom correspondence should be addressed

Received March 8, 1988. Revised October 27, 1988. Accepted October 27, 1988.

Antigen receptors on most T-cells are heterodimeric glycoproteins, comprised of an alpha chain and a beta chain. These chains are encoded by discontiguous variable (V), diversity (D) and joining (J) gene segments that rearrange to produce a contiguous and functional alpha or beta chain gene. To investigate the size and diversity of the germline repertoire of {alpha}-chain gene segments, we have characterized and sequenced 20 alpha chain cDNAs. Among these cDNA clones, we have found 4 J{alpha} and 4 V{alpha} sequences that have not yet been described. The relationship of these "new" gene segments to those already characterized is discussed.


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