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Corrigendum for Mita et al., Nucl. Acids Res. 16 (19) 9351.
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Nucleic Acids Research, 1988, Vol. 16, No. 23 11398-11402
© 1988

Corrigenda

A cDNA specifying the human amyloid ß precursor protein (ABPP) encodes a 95-kDa polypeptide

Shuji Mita, James Sadlock, Joseph Herbert and Eric A. Schon

It has come to our attention that a small 5' region of the cDNA encoding ABPP derived from {lambda}HAP2 contains an unusual cloning artifact that is almost certainly not present in the ABPP mature mRNA. The DNA sequence of the ABPP chromosomal gene published recently [ et al. (1988) EMBO J., 7, 2807] agrees completely with our sequence in the region downstream of nt 76; however, the {lambda}HAP2 cDNA sequence from at 1-nt 75 is not represented in the ABPP genomic sequence. Analysis of this region showed that nucleotides 14–82 in the {lambda}HAP2 cDNA form a perfect inverted repeat with a 69-nt region within the body of the authentic ABPP cDNA. This inverted region was most likely incorporated into the cDNA during library construction.


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