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Nucleic Acids Research, 1988, Vol. 16, No. 24 11507-11520
© 1988

MOLECULAR BIOLOGY

Cloning and characterization of the Saccharomyces cerevisiae CDC6 gene

Julianna Lisziewicz+, Andrej Godanyø, Denes V. Agoston§ and Hans Küntzel*

Max-Planck Institut für Experimentelle Medizin, Abteilung Chemie Hermann-Rein-Strasse 3, D-3400 Göttingen, FRG

*To whom correspondence should be addressed

Present addresses: +National Cancer Institute, NIH, DCE, Building 41, Bethesda, MD 20892

øPermanent address: Slovak Academy of Sciences, Institute of Molecular Biology, 84251 Bratislava, Czechoslovakia

Received September 23, 1988. Revised November 24, 1988. Accepted November 24, 1988.

The yeast cell division cycle gene CDC6 was isolated by complementation of a temperature-sensitive cdc6 mutant with a genomic library. The amino acid sequence of the 48 kDalton CDC6 gene product, as deduced from DNA sequence data, includes the three consensus peptide motifs involved in guanine nucleotide binding and GTPase activity, a target site for cAMP-dependent protein kinase and a carboxy-terminal domain related to metallothionine sequences. A plasmid-encoded CDC6-ß-galactosidase hybrid protein was located at the plasma membrane by indirect immunofluorescence. Disruption experiments indicate that the CDC6 gene product is essential for mitotic growth.

§Laboratory of Cell Biology, NIMH, Building 36, Bethesda, MD 20892, USA


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