Skip Navigation

This Article
Right arrow Print PDF (1864K)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Dolecki, G. J.
Right arrow Articles by Humphreys, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dolecki, G. J.
Right arrow Articles by Humphreys, T.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nucleic Acids Research, 1988, Vol. 16, No. 24 11543-11558
© 1988

MOLECULAR BIOLOGY

Stage- and tissue-specific expression of two homeo box genes in sea urchin embryos and adults

Gregory J. Dolecki*, Gordon Wang and Tom Humphreys

Pacific Biomedical Research Center, University of Hawaii 41 Ahui Street, Honolulu, HI 96813, USA

*To whom correspondence should be addressed at Kewalo Marine Laboratory, 41 Ahui Street, Honolulu, HI 96813, USA

Received September 7, 1988. Revised November 11, 1988. Accepted November 11, 1988.

We report the isolation of two different homeo box genes, HB3 and HB4, from the Hawaiian sea urchin Tripneustes gratilla. DNA sequencing revealed a definitive Antennapedia (Antp) class homeo box in each gene. Southern transfer hybridizations showed the genes to be single-copy. A 5.7-kb transcript of the HB3 gene was found in ovary, testis, small intestine and gastrula poly(A)+ RNA. The HB4 gene produces three transcripts. A 3.7-kb and a 4.4-kb transcript are expressed during embryogenesis. A 3.5-kb transcript appears in each of the adult tissues studied. The HB4 gene appears to be the sea urchin cognate of the Drosophila infrabdominal-7 (iab-7) gene, the mouse Hox 1.7 and Hox 3.2 genes and the Xenopus XlHbox 6 gene. An examination of Antp class homeo box genes in deuterostomes indicates that a chromosomal duplication has taken place in the evolutionary line leading to the vertebrates after the divergence of the echinoderms. Thus, the sea urchin represents the primitive condition.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 DevelopmentHome page
M Di Bernardo, S Castagnetti, D Bellomonte, P Oliveri, R Melfi, F Palla, and G Spinelli
Spatially restricted expression of PlOtp, a Paracentrotus lividus orthopedia-related homeobox gene, is correlated with oral ectodermal patterning and skeletal morphogenesis in late-cleavage sea urchin embryos
Development, January 5, 1999; 126(10): 2171 - 2179.
[Abstract] [PDF]

Home page
 Genes Dev.Home page
L M Angerer, G J Dolecki, M L Gagnon, R Lum, G Wang, Q Yang, T Humphreys, and R C Angerer
Progressively restricted expression of a homeo box gene within the aboral ectoderm of developing sea urchin embryos.
Genes & Dev., March 1, 1989; 3(3): 370 - 383.
[Abstract] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
P. Callaerts, P. N. Lee, B. Hartmann, C. Farfan, D. W. Y. Choy, K. Ikeo, K.-F. Fischbach, W. J. Gehring, and H. G. de Couet
HOX genes in the sepiolid squid Euprymna scolopes: Implications for the evolution of complex body plans
PNAS, February 19, 2002; 99(4): 2088 - 2093.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.