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Nucleic Acids Research, 1988, Vol. 16, No. 24 11617-11624
© 1988

MOLECULAR BIOLOGY

The unusually long amino acid acceptor stem of Escherichia coli selenocysteine tRNA results from abnormal cleavage by RNase P

Ulrike Burkard and Dieter Söll*

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School Boston, MA 02115, USA

*To whom correspondence should be addressed

Received July 19, 1988. Revised November 6, 1988. Accepted November 6, 1988.

The nucleotide sequence of the gene encoding the Eseherichia coli selenocysteine tRNA (tRNASeCys predicts an unusually long acceptor stem of 8 base pairs (one more than other tRNAs). Here we show by in vivo experiments (Northern blots, primer extension analysis) and by in vitro RNA processing studies that E. coli tRNASeCys does contain this additional basepair, and that its formation results from abnormal cleavage by RNase P.


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