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Nucleic Acids Research, 1988, Vol. 16, No. 3 1143-1151
© 1988

Articles

Human transposon-like elements insert at a preferred target site: evidence for a retrovirally mediated process

Niren Deka, Cary R. Willard, Elsie Wong and Carl W. Schmid

Department of Chemistry, University of California Davis, CA 95616, USA

Received October 13, 1987. Revised December 29, 1987. Accepted December 29, 1987.

Members of the human transposon-like family of repetitive sequences (called THE 1 repeats) like many other repetitive DNA sequences are flanked by short direct repeats. Comparison of the base sequences of twelve examples of these flanking direct repeats indicates that THE 1 repeats insert into a preferred genomic target site. In one case, we have identified the sequence of an empty site into which a THE 1 element inserted. The sequence of this empty site and sequences of truncated THE 1 LTRs are consistent with a retroviral mechanism for the insertion of THE 1 elements. Truncated transposon structures illustrate for the first time that intermediate structures of retrotransposition may also be integrated into the genome.


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