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Nucleic Acids Research, 1988, Vol. 16, No. 7 2959-2969
© 1988

Articles

Intergenic exchange maintains identity between two human lambda light chain immunoglobulin gene intron sequences

Jenny A. Udey1 and Bonnie B. Blomberg*

Department of Microbiology and Immunology, University of Miami Medical School PO Box 016960, Miami, FL 33101, USA

*To whom correspondence should be addressed

Received August 27, 1987. Revised February 25, 1988. Accepted February 25, 1988.

Evidence for gene conversion or unequal double crossover in the human {lambda} light chain imunoglobulin locus is presented. The high level of J2C2-J3C3 Intron cross-hybridization, the identity of the J{lambda}2 and J{lambda}3 coding and intron sequences, the presence of multiple base differences between the C{lambda}2 and C{lambda}3 coding regions, and the presence of both the unconverted and converted all eles in the normal gene pool, suggest that a recombinational event has resulted in the conversion of the J{lambda}2 coding and intron sequences to those of J{lambda}3 and Its flanking sequences. Intergenic exchanges, such as the one described here, may provide a mechanism to maintain sequence homogeneity and functionality among the duplicated members of the human lambda gene family.

1Present address: Department of Anatomy and Cell Biology, University of Miami Medical School, PO Box 016960, Miami, FL 33101, USA.


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