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Nucleic Acids Research, 1988, Vol. 16, No. 8 3255-3268
© 1988

Articles

Adenoslne deaminase gene expression is regulated posttranscriptionally in the nucleus

Th.M. Berkvens1,2, F. Schoute1,2, H. van Ormondt1, P.Meera Khan2 and A.J. van der Eb1

1Departments of Medical Biochemistry, Sylvius Laboratories Wassenaarseweg 72, 2333 AL Leiden, The Netherlands 2Departments of Human Genetics, Sylvius Laboratories Wassenaarseweg 72, 2333 AL Leiden, The Netherlands

Received January 7, 1987. Revised March 17, 1988. Accepted March 17, 1988.

The housekeeping enzyme adenoslne deaminase (ADA) shows a large variation in tissue-specific expression ranging from 1 Iu in red blood cells to 880 Iu in thymocytes. We investigated the acute lymphocytic leukemic cell line Molt-4 (660 Iu ADA/g protein) and the promyelocytic cell line HL-60 (38 Iu ADA/g protein) as a model system to determine the levels at which the tissue-specific expression of ADA is regulated. From our results 1t can be concluded that the almost 20-fold difference in ADA expression between Molt-4 and HL-60 is the result of differences in the post-transcriptional processing and/or stability of ADA pre-mRNA within the nucleus.


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