Skip Navigation

This Article
Right arrow Print PDF (1886K)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Razin, S.V.
Right arrow Articles by Georgiev, G.P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Razin, S.V.
Right arrow Articles by Georgiev, G.P.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nucleic Acids Research, 1988, Vol. 16, No. 9 3617-3633
© 1988

Articles

The distribution of tightly bound proteins along the DNA chain reflects the type of cell differentiation

S.V. Razin*, V.V. Chernokhvostov, E.S. Vassetzky, Jr, M.V. Razina and G.P. Georgiev

Institute of Molecular Biology, USSR Academy of Sciences 32 Vavilov str., 117984 Moscow B-334, USSR

*To whom correspondence should be addressed

Received February 24, 1988. Accepted April 4, 1988.

Distribution of proteins tightly bound to DNA (TBP) along the DNA chain was found to depend on the cell lineage. DNA sequences coding for alpha globin genes are preferentially represented in the TBP-associated DNA fractions isolated from erythroid cells (erythroblasts, mature erythrocytes, differentiated and non-differentiated Friend erythroleukemia cells), but not from cultured fibroblast cells. In transcriptionally active nuclei, complexes of TBP interact with the nuclear matrix, while in mature erythrocytes this interaction disappears.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.