Nucleic Acids Research, 1989, Vol. 17, No. 1 11-18
© 1989
MOLECULAR BIOLOGY |
Isolation of the Xenopus bomolog of int-1/wingless and expression during neurula stages of early development
Hubrecht Laboratory, Netherlands Institute for Developmental Biology Uppsalalaan 8, 3584 CT Utrecht 1Division of Molecular Biology, Netherlands Cancer Institute Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
*To whom correspondence should be addressed
Received October 20, 1988. Revised December 2, 1998. Accepted December 2, 1998.
We have isolated the Xenopus homolog (Xint-1) of the mouse protooncogene int-1 from a neurula stage 17 cDNA library. The deduced protein sequence of Xint-1 includes 371 amino acids. The Xint-1 protein is more similar to the mammalian int-1 product (69%), than to the Drosophila counterpart of int-1, wingless (50%). Xint-1 shares several characteristics of secreted proteins with the other int-1 homologs: it has a hydrophobic leader, multiple conserved potential N-linked glycosylation sites and is rich in cysteine residues. All 23 cysteines are conserved in the three proteins. Xint-1 is transiently expressed during the neurula stages of early Xenopus development.
+Present address: Laboratory for Physiological Chemistry, State University of Utrecht, Vondellaan 24a, 3521 GG Utrecht, The Netherlands
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