Nucleic Acids Research, 1989, Vol. 17, No. 1 225-238
© 1989
MOLECULAR BIOLOGY |
tRNA derived insertion element in histone gene repeating unit of Drosophila melanogaster
Laboratory of Population Genetics, Department of Biology, Faculty of Science, Kyushu University Fukuoka 812, Japan
**To whom correspondence should be addressed
Received September 7, 1988. Revised November 23, 1988. Accepted November 23, 1988.
Analysis of 41 histone homologous clones from an isogenic gene library of Drosophila melanogaster showed that non-histone fragments interrupt the histone repetitive clusters at several sites. Long (L) and short (S) forms of the repeating units are distinguished by the insertion of 240 bp into the spacer between H1 and H3 of the L units; Each form appears to be clustered with its own kind. The complete DNA sequence of the histone 5.0 kb repeating unit was determined. Five histone genes(H1, H2A, H2B, H3, H4) were identified in a repeating unit and several sequence blocks common to the five histone genes were found in the 5'- and 3'-regions. The insertion sequence of 240 bp was found to be similar to the Alu family, an element derived from tRNA.
* Present address: Department of Ecology, Ethology and Evolution, University of Illinois, Shelford Vivarium, 606 E. Heaky St., Champaign, Illinois 61820, USA
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