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Nucleic Acids Research, 1989, Vol. 17, No. 10 3763-3771
© 1989

MOLECULAR BIOLOGY

Chicken transferrin receptor gene: conservation 3' noncoding sequences and expression in erythroid cells

Lee-Nien L. Chan*, Nikos Grammatikakis+, Janet M. Banks§ and Elizabeth M. Gerhardt

Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch Galveston, TX 77550

*To whom correspondence should be addressed.

Received December 23, 1988. Revised April 10, 1989. Accepted April 10, 1989.

Recombinant clones of the chicken transferrin receptor gene and cDNA have been isolated anc sequenced. Two highly conserved regions have been identified in the 3' noncoding sequence of the human and chicken TR gene. The conserved regions include sequences that have been shown tc be involved in the iron-dependent regulation of human TR mRNA stability. These sequences car be modeled as two different types of RNA secondary structures, one containing stem-loop structures that are similar to the iron-responsive elements found in ferritin mRNA and the other being a stable, duplex/stem-loop structure. Both forms show considerable similarity between chicken and humar mRNA. The expression of TR is developmentally regulated during erythroid maturation, and immature erythroid cells express exceptionally high levels of TR mRNA.

+Present addresses: National Cancer Institute/Frederick Cancer Research Facility, Frederick, MD

§Present addresses: School of Nursing, University of Texas Medical Branch, Galveston, TX 77550, USA


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