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Nucleic Acids Research, 1989, Vol. 17, No. 11 4131-4144
© 1989

CHEMISTRY

Conformation and dynamics of Z-DNA oligomer duplex of d[(CG)3TATA(CG)3] in solution

Satoshi Ikuta and Yu-Sen Wang

Department of Chemistry, Illinois Institute of Technology Chicago, IL 60616, USA

Received December 5, 1988. Revised April 12, 1989. Accepted April 12, 1989.

The conformation and dynamics of a DNA oligomer, d[(CG)3TATA(CG)3], in AM NaC104 (Z-TATA 16 mer) have been studied by 1H NMR. The principal results of our investigation are: (i) at low temperature d[(CG)3TATA(CG)3] exists as duplexes in both low (0.1M NaCl) and high (AM NaC1044) ionic strength solutions; (ii) CGCGCG segments undergo the B-to-Z transition in AM NaC104; (iii) even in AM NaClO4 the TATA box exhibits non-Z-structures and possesses multiple conformations which are slowly exchanging on the NMR chemical shift difference time scale; and, (iv) the Z-type structure of the CGCGCG segments induced in AM NaClO4 is more conformationally mobile than its B-type counterpart in 0.1M NaCl on the nanosecond time scale.


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