Nucleic Acids Research, 1989, Vol. 17, No. 12 4433-4439
© 1989
MOLECULAR BIOLOGY |
Differential repair of UV damage in Saccharomyces cerevisiae
Leiden University, Gorlaeus Laboratories, Department of Molecular Genetics Einsteinweg 5, PO Box 9502, 2300 RA Leiden, The Netherlands
Received April 21, 1989. Revised May 24, 1989. Accepted .
Preferential repair of UV-induced damage is a phenomenon by which mammalian cells might enhance their survival. This paper presents the first evidence that preferential repair occurs in the lower eukaryote Saccharomyces cerevisiae. Moreover an unique approach is reported to compare identical sequences present on the same chromosome and only differing in expression. We determined the removal of pyrimidine dimers from two identical 
-mating type loci and we were able to show that the active MAT locus is repaired preferentially to the inactive HML locus. In a sir-3 mutant, in which both loci are active this preference is not observed.
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