Skip Navigation

This Article
Right arrow Print PDF (588K)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (68)
Right arrowRequest Permissions
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Holt, I.J.
Right arrow Articles by Morgan-Hughes, J.A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Holt, I.J.
Right arrow Articles by Morgan-Hughes, J.A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nucleic Acids Research, 1989, Vol. 17, No. 12 4465-4469
© 1989

MOLECULAR BIOLOGY

Deletions of muscle mitochondrial DNA in mitochondrial myopathies: sequence analysis and possible mechanisms

I.J. Holt, A.E. Harding* and J.A. Morgan-Hughes

University Department of Clinical Neurology, Institute of Neurology Queen Square, London WC1N 3BG, UK

*To whom correspondence should be addressed

Received April 14, 1989. Revised May 22, 1989. Accepted May 22, 1989.

Forty per cent of patients with mitochondrial myopathies, a diverse group of multisystem diseases predominantly affecting skeletal muscle and the brain, have large deletions of a proportion of muscle mitochondrial DNA (mt DNA). These appeared to be identical in 13 of 28 cases, contained within the region 8286–13595 bp. Analysis of the deletion junction in two cases showed a 13 nucleotide sequence which occurred in the normal genome as a direct repeat flanking the region deleted in the mutant mt DNAs. Mt DNA deletions may arise from recombination or slippage between short sequence repeats during replication.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Neurosci.Home page
A. M. Celotto, A. C. Frank, S. W. McGrath, T. Fergestad, W. A. Van Voorhies, K. F. Buttle, C. A. Mannella, and M. J. Palladino
Mitochondrial Encephalomyopathy in Drosophila
J. Neurosci., January 18, 2006; 26(3): 810 - 820.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
M. R. Rose
Mitochondrial Myopathies: Genetic Mechanisms
Arch Neurol, January 1, 1998; 55(1): 17 - 24.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.