Skip Navigation

This Article
Right arrow Print PDF (443K)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (59)
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Shen, Z.
Right arrow Articles by Fox, T. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Shen, Z.
Right arrow Articles by Fox, T. D.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nucleic Acids Research, 1989, Vol. 17, No. 12 4535-4539
© 1989

MOLECULAR BIOLOGY

Substitution of an invariant nucleotide at the base of the highly conserved ‘530–loop’ of 15S rRNA causes suppression of yeast mitochondrial ochre mutations

Zonghou Shen* and Thomas D. Fox

Section of Genetics and Development, Cornell University Ithaca, NY 14853-2703, USA

Received March 31, 1989. Accepted May 9, 1989.

We have determined the nucleotide sequence alteration in the 15S rRNA gene of a Saccharomyces cerevisiae strain carrying the previously described mitochondrial ochre suppressor, MSU1. The suppressor contains an A residue at position 633 of the yeast mitochondrial sequence, in place of the wild–type G. This position, located in the highly conserved region forming the stem of the ‘530-loop’, corresponds to G517 of the Escherichia coli 16S rRNA and is occupied by G in all other known small rRNA sequences. This finding strongly supports the previous conclusions of others that the 530–loop region plays an important role in enhancing translational accuracy.

*Present address: Department of Biology, t.Jmversity of Wuhan, wuhan, China


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
F. Tavares-Carreon, Y. Camacho-Villasana, A. Zamudio-Ochoa, M. Shingu-Vazquez, A. Torres-Larios, and X. Perez-Martinez
The Pentatricopeptide Repeats Present in Pet309 Are Necessary for Translation but Not for Stability of the Mitochondrial COX1 mRNA in Yeast
J. Biol. Chem., January 18, 2008; 283(3): 1472 - 1479.
[Abstract] [Full Text] [PDF]

Home page
 Eukaryot CellHome page
E. H. Williams, N. Bsat, N. Bonnefoy, C. A. Butler, and T. D. Fox
Alteration of a Novel Dispensable Mitochondrial Ribosomal Small-Subunit Protein, Rsm28p, Allows Translation of Defective COX2 mRNAs
Eukaryot. Cell, February 1, 2005; 4(2): 337 - 345.
[Abstract] [Full Text] [PDF]

Home page
 RNAHome page
E. H. WILLIAMS and T. D. FOX
Antagonistic signals within the COX2 mRNA coding sequence control its translation in Saccharomyces cerevisiae mitochondria
RNA, April 1, 2003; 9(4): 419 - 431.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
K. Lee, C. A. Holland-Staley, and P. R. Cunningham
Genetic Approaches to Studying Protein Synthesis: Effects of Mutations at {Psi}516 and A535 in Escherichia coli 16S rRNA
J. Nutr., November 1, 2001; 131(11): 2994S - 3004.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
N. Bonnefoy, N. Bsat, and T. D. Fox
Mitochondrial Translation of Saccharomyces cerevisiae COX2 mRNA Is Controlled by the Nucleotide Sequence Specifying the Pre-Cox2p Leader Peptide
Mol. Cell. Biol., April 1, 2001; 21(7): 2359 - 2372.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
R. L. Souza, N. S. Green-Willms, T. D. Fox, A. Tzagoloff, and F. G. Nobrega
Cloning and Characterization of COX18, a Saccharomyces cerevisiae PET Gene Required for the Assembly of Cytochrome Oxidase
J. Biol. Chem., May 12, 2000; 275(20): 14898 - 14902.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.