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Nucleic Acids Research, 1989, Vol. 17, No. 13 4975-4992
© 1989

MOLECULAR BIOLOGY

Cooperative interaction of chicken lysozyme enhancer sub-domains partially overlapping with a steroid receptor binding site

Joachim Altschmied+, Marc Muller, Aria Baniahmad, Christof Steiner and Rainer Renkawitz*

Genzentrum, Max- Planck-Institut for Biochemie D-8033 Marunsried, FRG

*To whom correspondence should be addressed

Received April 18, 1989. Revised June 5, 1989. Accepted June 5, 1989.

Expression of the lysozyme gene is a marker for the differentiation of macrophages, lysozyme transcription being gradually increased during maturation. We have analyzed the fine structure and function of two macrophage-specific enhancer elements of the chicken lysozyme gene (E-2.7 kb and E-0.2 kb). Both increase their activities upon LPS induction, both contain multiple binding sites for similar or identical nuclear factors and both can be divided into two functional modules. For the E-0.2 kb enhancer we found a synergistic activity of the modules to be dependent on their distance. Binding sites for nuclear proteins within enhancer E-0.2kb overlap substantially with the previously identified progesterone/glucocorticoid receptor binding site, which is required for steroid induction of lysozyme transcription in the oviduct.

+Present address: Salk Institut, La Joll, CA 92037, USA


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