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Nucleic Acids Research, 1989, Vol. 17, No. 13 5349-5360
© 1989

MOLECULAR BIOLOGY

A self-splicing intron in the small subunit rRNA gene of Pneumocystis carinii

Mitchell L. Sogin and Jeffrey C. Edman1

Division of Molecular and Cellular Biology in Department of Pediatrics, NationalJewish Center for Immunology and Respiratory Medicine 1400 Jackson Street, Denver, CO 80206 Department of Microbiology and Immunology, University of Colorado Health Sciences Center Denver, CO 80206 1Hormone Research Institute and the Department of LaboratoryMedicine, University of California San Francisco, CA 94143-0534, USA

Received December 20, 1988. Revised June 9, 1989. Accepted June 9, 1989.

The coding region for the Pneumocyststis carinii small subunit rRNA (16S–like rRNA) contains 390 extra ba3e pairs in a region that is highly conservedin other eukaryotic rRNA genes. The sequence has all the elementscharacteristic of group I self-splicing introns and interrupts thephylogenetically conserved helix proximal to the 3' terminus of the 16S–like rRNA. In vitro transcripts containing the putative group I intronwere capable of undergoing a "self-splicing" reaction which required the presenceof guanine nucleotide.


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