Nucleic Acids Research, 1989, Vol. 17, No. 14 5477-5488
© 1989
MOLECULAR BIOLOGY |
Identification of two transactlvation domains in the mouse oestrogen receptor
Molecular Endocrinology Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields LondonWC2A 3PX, UK
Received May 15, 1989. Accepted June 14, 1989.
We have identified two discrete transactivation domains within the mouse oestrogen receptor whose relative activities vary according to the target promoter. One domain lies within the N-terminal region and is active in the absence of oestradiol. The second domain is contained within the C-terminal portion of the protein and depends upon oestrogen binding for its activity. The location and oestrogen dependence of this domain has been confirmed using chimaeric receptors containing the Lex A DNA binding domain. Although transactivation by the C-terminal domain is dependent upon ligand binding the analysis of receptor deletion mutants has demonstrated that these two functions are not entirely coincident.
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|
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|
|
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|
|
|
|
 |
|
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|
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|
|
|
|
 |
|
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