Nucleic Acids Research, 1989, Vol. 17, No. 14 5489-5500
© 1989
MOLECULAR BIOLOGY |
Isolation of human cDNA clones of ski and the ski-related gene, sno
Molecular Oncology Laboratory, Nippon Veterinary and Zootechnical College Sakuragi, 1-10-19 Uenosakuragi, Taito-ku, Tokyo 110 1Laboratory of Physical and Chemical Research RIKEN, 3-1-1 Koya—dai, Tsukuba, Ibaraki 305 2Division of Cancer Research, Medical Research Institute Kanazawa Medical University, Uchinada, Ishikawa 920-02, Japan
*To whom correspondence should be addressed
Received May 8, 1989. Revised June 26, 1989. Accepted June 26, 1989.
cDNA clones of ski and the ski-related gene, sno, were obtained by screening human cDNA libraries. The predicted open reading frame of h-ski could encode a protein of 728 amino acid residues. The h-ski protein is highly homologous with the v-ski protein. The overall homology between b-ski and v-ski is 91% at the amino acid level. DNA sequencing analysis revealed two types of cDNA clones from the sno (ski-related novel gene) gene, possibly due to alternative splicing. The first type, named snoN (non Alu-containing), encoded a protein of 684 amino acid residues. The second type, named snoA (
llu-containing), encoded a protein of 415 amino acid residues. The first 366 amino acid residues of snoN and snoA are the same, but subsequent amino acids show divergence. Several transcripts of h-ski (6.0, 4.7, 3.8, 3.0, 2.1 and 1.8kb) were detected. The mRNAs of h-sno were 6.2, 4.4 and 3.2kb.
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