Nucleic Acids Research, 1989, Vol. 17, No. 14 5701-5711
© 1989
MOLECULAR BIOLOGY |
Conservation of the secondary structure elements of the 5' untranslated region of cardio- and aphthovirus RNAs
Institute of Poliomyelitis and Viral Encephalitides, USSR Academy of Medical Sciences Moscow region 142782, USSR
Received May 11, 1989. Revised June 15, 1989. Accepted June 16, 1989.
An analysis of published nucleotide sequences of the 5’-untranslated region t5’-UTR) of 7 cardioviruses and 3 aphthoviruses has allowed us to derive a consensus secondary structure model that differs from that previously proposed for the 5’-UTR of entero- and rhinoviruses, though all these viruses belong to the same family,Picornaviridae. The theoretical model derived here was experimentally supported by investigating the accessibility of encephalomyocarditis virua RNA to modifications with dimethyl sulfate and its susceptibility to S1 and cobra venom nucleases. The possible involvement of the 5’-UTR secondary structure domains in the translational control is briefly discussed.
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