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Nucleic Acids Research, 1989, Vol. 17, No. 15 5913-5922
© 1989

MOLECULAR BIOLOGY

Identification of new human repetitive sequences: characterization of the corresponding cDNAs and their expression in embryonal carcinoma cells

Girolama La Mantia*, Gina Pengue, Domenico Maglione, Antonio Pannuti, Anna Pascucci and Luigi Lania

Dipartimento di Genetica, Biologia Generale e Molecolare, University of Naples Via Mezzocannone 8, 80134 Naples, Italy

*To whom correspondence should be addressed

Received June 8, 1989. Accepted July 6, 1989.

We have identified new repeated interspersed DNA sequences by analysis of homologous RNA transcripts from a human teratocarcinoma cell line (NTERA-2 clone D1). The abundance of transcripts varies upon retinoic acid induced differentiation of NTERA-2/D1 cells, and it is highest when the cells display the embryonal carcinoma phenotype. The expression of these novel repeated sequences appears to be tissue specific as no detectable expression was found in various cell lines of different embryological derivation. Characterization of the RNA transcripts by analysis of recombinant cDNA clones indicated that transcripts of different genomic units are present in undifferentiated embryonal teratocarcinoma cells. Nucleotide sequencing of the cloned cDNAs reveals a complex structure composed by unique and tandemly repeated sub-elements.


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