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Nucleic Acids Research, 1989, Vol. 17, No. 15 6181-6189
© 1989

MOLECULAR BIOLOGY

Variation in G+C-content and codon choice: differences among synonymous codon groups in vertebrate genes

A. Martín*, J. Bertranpetit1, J.L. Oliver2 and J.R. Medina

Departimento de Genéica y Biotecnia, Facultad de Biología, Universidad de Sevilla Aptdo 1095, E-41080 Seville 1Departimento de Biología Animal, Facultad de Biología, Universidad de Barcelona Avda Diagonal 645, E-08028 Barcelona 2Unidad de Genética, Facultad de Ciencias, Universidad de Granada E-18071 Granada, Spain

*To whom correspondence should be addressed

Received March 17, 1989. Revised June 1, 1989. Accepted June 26, 1989.

The relationship between G+C-content and codon usage in genes of human, mus, rat, bovine and chicken nuclear genomes was investigated. Correlation and lineal regression analyses were carried out on plots that related the frequency of each codon within each synonymous codon group to the G+C-content of the coding sequence as a whole. Under GC pressure, in most of the quartet codon groups there is a preferential choice of the C-ending codon, except in leucine and valine codon groups where the choice of the G-ending codon is preferred. Among duets, the choice of codons specifying phenylalanine and glutamate shows the strongest dependence on G+C-content. The relationship found between G+C-content and codon usage in these genomes correlate with taxonomic distance.


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B. Zeeberg
Shannon Information Theoretic Computation of Synonymous Codon Usage Biases in Coding Regions of Human and Mouse Genomes
Genome Res., June 1, 2002; 12(6): 944 - 955.
[Abstract] [Full Text] [PDF]


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