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Nucleic Acids Research, 1989, Vol. 17, No. 15 6369-6382
© 1989


MOLECULAR BIOLOGY

Statistical analysis of mammalian pre-mRNA splicing sites

M.S. Gelfand

Institute of Protein Research, USSR Academy of Sciences Puschino, Moscow region 142292, USSR

Received February 4, 1989. Revised June 22, 1989. Accepted June 22, 1989.

222 donor and 222 acceptor (including 206 pairs) non-homologous splicing sites were studied. Well known features of these were confirmed and some novel observations were made. It is (1) cCAGGGag signal in (–60)–(–58) region of acceptor sites; (2) strong complementarity between regions (–69)–(–55) and (–36)–(–22) of some of the acceptor sites, and (3) small but statistically significant correlation between discrimination energies of corresponding donor and acceptor sites.


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