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Nucleic Acids Research, 1989, Vol. 17, No. 17 6841-6854
© 1989

MOLECULAR BIOLOGY

Detection and cloning of new HTLV-related endogenous sequences in man

Andras Perl1,*, Joseph D. Rosenblatt3, Irvin S. Y. Chen3, John P. DiVincenzo1, Robert Bever2, J. Poiesz4 and George N. Abraham1,2

1Department of Medicine, University of Rochester School of Medicine Rochester, NY 14642 2Department of Microbiology and Immunology, University of Rochester School of Medicine Rochester, NY 14642 3Divisiono of Hematology-Oncology, Department of Medicine UCLA, Los Angeles, CA 90024 4Department of Medicine, SUNY School of Medicine Syracuse, NY

*To whom correspondence should be addressed at Department of Molecular Medicine and Immunology, Roswell Park Memorial Institute, Buffalo, NY 14263, USA

Received June 30, 1989. Accepted July 27, 1989.

Human T-leukemia virus (HTLV) type I-related endogenous sequences (HRES) have been cloned from a human genomic libraty. HRES-1/1 is present in DNA of all normal donors examined. By nucleotide sequence analysis, HRES-1/1 contains two potential open reading frames capable of encoding a p25 and a p15. A 684 bp flanking region 5' from the first ATG codon of p25 contains a TATA-box, a poly-adenylation signal, a putative tRNA primer binding site, and inverted repeats at locations which are typical of a retroviral long terminal repeat. Phylogenetic analysis suggests that HRES-1/1 entered the genome in primates, presumably as an exogenous retrovirus. From the deduced amino acid sequence of HRES-1/1 p25, residues 6–36 show a sequence homology of 32% and 39% to gag region segments of HTLV-I and HTLV-II, while residues 104–139 display a sequence homology of 33% and 28% to the gag regions of human immunodeficiency virus type 2 (HIV-2) and feline sarcoma vints (FSV), respectively. This suggests that the original exogenous virus infecting primate may be chimeric in structure. The HRES-1/1 genomic locus is transcriptionally active in lymphoid cells, melanoma cells, and embryonic tissues.


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