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Nucleic Acids Research, 1989, Vol. 17, No. 17 7089-7099
© 1989

MOLECULAR BIOLOGY

Tissue-specific hypomethylation of the human c-K-ras gene

John Metter and Chong Cho

Department of Pathology, The University of Texas, Health Science Center San Antonio, TX 78284, USA

Received March 8, 1989. Revised July 31, 1989. Accepted July 31, 1989.

Methylation of the c-K-ras gene was examined in a wide variety of human tissues using the methylation sensitive restriction endonuclease Hpall. All tissues showed hypomethylation in the region of exon zero. Specific hypomethylation of a particular Hpall site in the second intron was observed in gastrointestinal and tracheobronchial epithelial cell DNAs. Specific hypomethylation was also observed in a cluster of Hpall sites within the first intron in sperm, endometrium and placenta DNAs. These regions were predominantly methylated in a wide variety of other tissues, including fetal gut. The possible implications are discussed.


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