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Nucleic Acids Research, 1989, Vol. 17, No. 18 7273-7281
© 1989

MOLECULAR BIOLOGY

DNA duplex with the potential to change handedness after every half a turn

Samir K. Brahmachari*, Rakesh K. Mishra+, Rajesh Bagga and N. Ramesh

Molecular Biophysics Unit, Indian Institute of Science Bangalore 560 012, India

*To whom correspondence should be addressed

+Present address: Centre for Cellular and Molecular Biology, Hyderabad, India

Received June 15, 1989. Revised August 21, 1989. Accepted August 21, 1989.

Polymorphic forms of the DNA duplex with long stretches of structural monotony are known. Several alternating purine-pyrimidine sequences have been shown to adopt left-handed Z-conformation. We report a DNA sequence d(CGCGCGATCGAT)n exhibiting alternating right-handed B and left-handed Z helical conformation after every half a turn. Further, this unusual conformation with change in handedness after every six base pairs was induced at physiological superhelical density


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