Nucleic Acids Research, 1989, Vol. 17, No. 18 7325-7331
© 1989
MOLECULAR BIOLOGY |
Rapid segregation of heteroplasmic bovine mitodiondria
Departments of Immunology and Medical Microbiology Opthalmology FL 32610–0266, USA 1Biochemistiy and Molecular Biology, University of Florida, College of Medicine Gainesville, FL 32610–0266, USA
*To whom correspondence should be addressed
+ Present address: Department of Biology, Lake Forest College, Lake Forest, IL 60045, USA
Received May 30, 1989. Revised August 16, 1989. Accepted August 16, 1989.
By following the transmission of a heteroplasmic mitochoralrial DNA mutation through four generations of Holstein cows, we have documented that substantial shifts in the levels of heteroplasmy can occur between single mammalian generations, that neutral mitochondrial genotypes can segregate in different directions in offspring of the same female, and that a return to homoplasmy may occur in only two or three generations. This apparently rapid rate of mitochondrial DNA segregation in mammals contrasts to the much slower rates observed previously in insects and suggest fundamental differences between taxa regarding the mechanisms of mitochondrial gene transmission
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