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Nucleic Acids Research, 1989, Vol. 17, No. 18 7453-7467
© 1989

MOLECULAR BIOLOGY

A single-straded RNA copy of the Giardia lamblia virus double-stranded RNA genome is present in the infected Giardia lamblia

Eric S. Furfine, Therodore C. White, Alice L. Wang and Ching C. Wang*

Box 0446, School of Pharmacy, Department of Pharmaceutical Chemistry, University of California San Francisco, CA 94143, USA

*To whom correspondence should be addressed

Received June 26, 1989. Revised August 17, 1989. Accepted August 17, 1989.

An isolate of Giardia lamblia infected with the double-stranded RNA virus (GLV) has two major species of RNA that are not present in an uninfected isolate. One of these species is the previously characterized double-stranded RNA genome of GLV (1). The second species of RNA appears to be a full length copy of one strand of the double-stranded RNA genome. This full length single-stranded RNA is not present in viral particles isolated from the growth medium. The cellular concentration of the single-stranded RNA changes during exponential and stationary phases of cell growth in a fashion consistent with a viral replicative intermediate or mRNA. The single-stranded species does not appear to be polyadenylated.


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