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Nucleic Acids Research, 1989, Vol. 17, No. 19 7771-7778
© 1989

MOLECULAR BIOLOGY

A cis-acting transcription element of the c-myc gene can assume an H-DNA conformation

Alan J. Kinniburgh

Department of Human Genetics, Roswell Park Memorial Institute Elm and Carlton Streets, Buffalo, NY 14263, USA

Received June 26, 1989. Revised August 23, 1989. Accepted August 23, 1989.

I have used chemical probes and an oligonucleotide-association assay to determine the structure of a nuclease-sensitive, c-myc DNA region. I find that this DNA region can form a triplex-single stranded conformer in vitro—the H-DNA conformer. This DNA region has been shown previously to be a positive, cis-acting transcription element of the c-myc gene and to bind nuclear factors, including a base-paired ribonucleoprotein10. Therefore, H-DNA may be a functionally important in vivo topoisomer where the H-DNA and B-DNA conformers have different transcriptional activities.


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