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Nucleic Acids Research, 1989, Vol. 17, No. 20 8327-8341
© 1989

MOLECULAR BIOLOGY

Recombination mediates production of an extrachromosomal circular DNA containing a transposon-like human element, THE-1

Ravi Misra, A. Gregory Matera1, Carl W. Schmid1 and Mark G. Rush

Department of Biochemistry, New York University School of Medicine New York, NY 10016 USA 1Department of Chemistry, University of California Davis, CA 95616, USA

Received June 2, 1989. Revised September 7, 1989. Accepted September 7, 1989.

An abundant class of HeLa extrachromosomal circular DNA containing the transposon-like element, THE-1, is shown to arise via site specific recombination. The chromosomal locus from which these circles are derived, however, is single-copy. Northern blot analysis detects homology to two polyadenylated RNAs in HeLa cells. The possible presence of an origin of replication and its role in generating these small polydisperse circles is discussed.


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