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Nucleic Acids Research, 1989, Vol. 17, No. 21 8669-8682
© 1989

MOLECULAR BIOLOGY

In vivo transcription of a cloned prosimian primate SINE sequence

Valerie K. Slagel* and Prescott L. Deininger1

Department of Biological Chemistry, UCLA School of Medicine Los Angeles, CA 90024, USA 1Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center New Orleans, LA 70112, USA

*To whom correspondence should be addressed

Received April 14, 1989. Revised May 30, 1989. Accepted September 26, 1989.

SINE transcription was studied by introducing a galago Monomer family member (gal39), into the mouse Ltk– cell line. Cells transiently transfected with gal39 produce gal39-specific RNA polymerase III-directed transcripts. In permanent cell lines gal39 expression was largely shut off. Genomic environment, copy number and tandem repetition of integrated SINE sequences influenced whether or not RNA polymerase III-directed gal39 transcripts were detectable. These transcripts differ in length from the observed endogenous transcript in cultured galago cells which hybridizes to this repetitive DNA family.


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