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Nucleic Acids Research, 1989, Vol. 17, No. 22 9395-9405
© 1989

MOLECULAR BIOLOGY

Structure and functional expression of a cloned Xenopus thyroid hormone receptor

A.R. Brooks, G. Sweeney and R.W. Old*

Department of Biological Sciences, University of Warwick Coventry CV4 7AL, UK

*To whom correspondence should be addressed

Received September 8, 1989. Revised October 17, 1989. Accepted October 17, 1989.

A clon corresponding to a thyroid hormone receptor was isolated from a Xenopus laevis cDNA library prepared from folliculated oocytes. The cDNA encodes a protein of 418 amino acid residues with a domain structure, including a putative DNA binding region with two zinc fingers, similar to other members of the v-erbA-related superfamily of receptors. The encoded protein resembles the TR{alpha}1-type receptor of the rat. When expressed in COS cells the protein product binds triiodothyronine with a Kd of 0.12 nM. The receptor mediates thyroid-hormone-inducible expression of a reporter gene which includes a thyroid hormone response element in its upstream region.


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