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Nucleic Acids Research, 1989, Vol. 17, No. 22 9407-9415
© 1989

MOLECULAR BIOLOGY

A negative regulatory element in the promoter of the human {alpha}1-antitrypsin gene

Vincenzo De Simone* and Riccardo Cortese

European Molecular Biology Laboratory (EMBL) Meyerhofstrasse 1, 6900 Heidelberg, FRG

*To whom correspondence should be addressed

Received September 5, 1989. Revised October 13, 1989. Accepted October 13, 1989.

A "minimal tissue-specific element" of the human {alpha}1-antitrypsin ({alpha}1-AT) gene promoter, located in the –137/–37 region, is able to drive hepatoma-specific transcription from the heterologous SV40 promoter. Here we show that, in HeLa cells, this element is inactivated by a negative regulatory mechanism. This negative control can be overcome by deletion or mutation of two specific DNA domains.


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