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Nucleic Acids Research, 1989, Vol. 17, No. 23 9797-9809
© 1989

MOLECULAR BIOLOGY

Direct evidence for intrastrand DNA inversion of x immunoglobulin gene segments in two murine plasmacytomas

Rodney Feddersen1,2 and Brian Van Ness1,*

1Institute of Human Genetics and Department of Biochemistry, University of Minnesota Minneapolis, MN 55455 2The University of Iowa Iowa City, IA 52242, USA

*To whom correspondence should be addressed

Received August 7, 1989. Revised November 2, 1989. Accepted November 2, 1989.

The products of kappa immunoglobulin gene recombination have been characterized in two murine plasmacytomas to examine the relationship between V-J products and reciprocal elements. By cloning, sequencing, hybridization, and application of the polymerase chain reaction, we have established the direct relationship of the kappa recombination products in these cells. The results provide stronger support for the intrastrand mechanism of kappa gene recombination as well as demonstrating a role for secondary, corrective recombinations.


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