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Nucleic Acids Research, 1989, Vol. 17, No. 23 9871-9888
© 1989

MOLECULAR BIOLOGY

The XLR sequence family: dispersion on the X and Y chromosomes of a large set of closely related sequences, most of which are pseudogenes

Henri-Jean Garchon1,2, Elwyn Loh1, William Y. Ho1, Laurence Amar3, Philip Avner3 and Mark M. Davis1

1Department of Microbiology and Immunology, Stanford University School of Medicine and The Howard Hughes Medical Institute Stanford, California, USA 2INSERM U 25, Hôpital Necker Paris 3Unité d'Immunogénétique Humaine. Institut Pasteur Paris, France

Received February 13, 1989. Revised October 16, 1989. Accepted October 27, 1989.

The XLR sequence family encodes RNA transcripts specific to late-stage T and B cells and their neoplasms. Only one apparently functional mRNA has been identified thus far and this encodes a novel 25 kDa nuclear protein. In this report, we find that the XLR gene family is composed of 50–75 copies per haploid genome which localize to at least two different portions of the mouse X chromosome. Neither of these locations are near the xid mutation that earlier work had correlated with XLR. In addition, some members of this family are also on the Y chromosome. Another surprising finding is that while the fourteen genomic clones examined to date have the same exon-intron structure and are closely related with respect to sequence conservation (90%), all appear (in most cases by multiple criteria) to be non-functional, raising the possibility that all but one of the members of this large semi-dispersed family are pseudogenes.


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