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Nucleic Acids Research, 1989, Vol. 17, No. 4 1353-1369
© 1989

ENZYMOLOGY

The acid phosphatase genes PHO10 and PHO11 in S.cerevisiae are located at the telomeres of chromosomes VIII and I

Ulrike Venter and Wolfram Hörz

Institut für Physiologische Chemie, Universität München Schillerstr. 44, 8000 München 2, FRG

Received January 5, 1989. Accepted January 26, 1989.

Of the three regulated acid phosphatase genes in S.cerevisiae (PH05, PH010 and PH011) two have previously been cloned (PH05 and PH011). We have now identified PH010 and show by restriction mapping that it is highly homologous to PHO11. This homology includes not only the coding sequence but also a stretch of about 2 kb upstream and 2.2 kb downstream of the genes. Analysis of strains in which either gene had been disrupted shows that the two genes are located at the telomeres of two different chromosomes. PH010 ends about 9 kb from the end of chromosome VIII and PH011 3.6 Rb from the end of chromosome I. This makes PH011 the gene closest to the end of a chromosome that has been physically mapped so far in S.cerevisiae. The organization of the two genes varies strongly from strain to strain consistent with a high incidence of telomere rearrangement. In one of twenty transformants examined a conversion event could be directly demonstrated that resulted in a chromosome VIII which had acquired a copy of the telomere from chromosome I.


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