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Nucleic Acids Research, 1989, Vol. 17, No. 4 1733-1743
© 1989

MOLECULAR BIOLOGY

A comparison of snRNP-associated Sm-autoantigens: human N, rat N and human B/B'

Claudia Schmauss*, George McAllister, Yasuo Ohosone1, John A. Hardin1 and Michael R. Lerner

Section of Molecular Neurobiology, Howard Hughes Medical Institute Research Laboratories 333 Cedar Street, PO Box 3333, New Haven, CT 06510, USA 1Department of Internal Medicine, Section of Rheumatology, Yale University School of Medicine 333 Cedar Street, PO Box 3333, New Haven, CT 06510, USA

*To whom correspondence should be addressed

Received September 22, 1988. Accepted January 16, 1989.

N is a tissue-specific, Sm-epitope bearing, snRNP-associated protein found predominantly in brain. The cDNA sequence encoding human N is compared to those for rat N and human B/B'. The amino acid sequences of human and rat N are 100% conserved. Although the amino acid sequences of N and B/B' are very similar to each other, B7sol;B' contains 50 amino acids which are not present in N. On Northern blots the cDNAs encoding N and B/B' recognize two different RNA species. A comparison of the codon usage, as specified by the open reading frames of N and B/B' as well as results from Southern blots, show that N and B/B' are derived from different genes.


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