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Nucleic Acids Research, 1989, Vol. 17, No. 8 2897-2905
© 1989


CHEMISTRY

Synthesis of the nucleopeptides H-Phe-Tyr(pGC)-NH2 and H-Phe-Ser(pGC)-Ala-OH via a phosphotriester approach

E. Kuyl-Yeheskiely, C.M. Dreef-Tromp, A. Geluk, G.A. van der Marel and J.H. van Boom

Gorlaeus Laboratories, Leiden University PO Box 9502, 2300 RA Leiden, The Netherlands

Received February 21, 1989. Accepted March 17, 1989.

Use of the protecting groups di-n-butylaminomethylene,2-nitrophenylsulfenyl and the ester of 2-(hydroxymethyl)-9,10-anthraquinone, enabled us for the first time to prepare nucleopeptide fragments containing 2'-deoxyguanosine and a free carboxylic acid group.


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