Nucleic Acids Research, 1989, Vol. 17, No. 8 2897-2905
© 1989
CHEMISTRY |
Synthesis of the nucleopeptides H-Phe-Tyr(pGC)-NH2 and H-Phe-Ser(pGC)-Ala-OH via a phosphotriester approach
Gorlaeus Laboratories, Leiden University PO Box 9502, 2300 RA Leiden, The Netherlands
Received February 21, 1989. Accepted March 17, 1989.
Use of the protecting groups di-n-butylaminomethylene,2-nitrophenylsulfenyl and the ester of 2-(hydroxymethyl)-9,10-anthraquinone, enabled us for the first time to prepare nucleopeptide fragments containing 2'-deoxyguanosine and a free carboxylic acid group.